DDW 2013: Interferon-free Simeprevir + Sofosbuvir Suppresses Hepatitis C with or without Ribavirin
- Details
- Category: HCV Treatment
- Published on Thursday, 30 May 2013 00:00
- Written by Liz Highleyman
An all-oral regimen consisting of simeprevir (formerly TMC435) plus sofosbuvir, (formerly GS-7977), with or without ribavirin, produced an 8-week post-treatment cure for most prior null responders with genotype 1 hepatitis C in the COSMOS trial, according to a poster presented at the Digestive Disease Week meeting (DDW 2013) last week in Orlando.
DDW 2013: Advanced Fibrosis Does Not Affect Response to Faldaprevir All-oral Regimen
- Details
- Category: HCV Treatment
- Published on Wednesday, 22 May 2013 00:00
- Written by Liz Highleyman
An interferon-free combination of faldaprevir, BI 207127, and ribavirin produced high and similar sustained response rates for treatment-naive genotype 1b hepatitis C patients with either absent-to-moderate liver fibrosis or advanced fibrosis/cirrhosis, according to a presentation at the Digestive Disease Week conference (DDW 2013) this week in Orlando.
DDW 2013: Does Treating Herpes Help Suppress Hepatitis C Virus?
- Details
- Category: HCV Treatment
- Published on Wednesday, 22 May 2013 00:00
- Written by Liz Highleyman
Treating herpes simplex virus type 2 (HSV-2) with valacyclovir (Valtrex) was associated with a substantial reduction in plasma hepatitis C virus levels in dually-infected individuals, according to a small study presented at the Digestive Disease Week conference (DDW 2013)this week in Orlando.
DDW 2013: Viral Breakthrough May Occur during Interferon/Ribavirin 'Tail' of HCV Triple Therapy
- Details
- Category: HCV Treatment
- Published on Wednesday, 22 May 2013 00:00
- Written by Liz Highleyman
HCV viral breakthrough is an ongoing possibility during the pegylated interferon/ribavirin continuation phase after triple therapy with telaprevir (Incivek or Incivek or Incivo), especially for difficult-to-treat patients, researchers reported this week at the Digestive Disease Week conference (DDW 2013) in Orlando.
DDW 2013: Simeprevir Boosts Response to Interferon-based Therapy for Prior Relapsers
- Details
- Category: HCV Treatment
- Published on Wednesday, 22 May 2013 00:00
- Written by Liz Highleyman
Adding the HCV protease inhibitor simeprevir (formerly TMC435) to pegylated interferon and ribavirin cured 79% of prior relapsers, and most were eligible to complete treatment after 3 months, according to findings from the PROMISE study presented at the Digestive Disease Week meeting (DDW 2013) this week in Orlando.
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