Immune Response
Immune Response to HIV
Studies Advance Understanding of Broadly Neutralizing Antibodies Against HIV
- Details
- Category: HIV Vaccines
- Published on Thursday, 09 July 2015 00:00
- Written by Rockefeller University
Three recent studies funded by the National Institutes of Health have shed further light on broadly neutralizing antibodies that may play a role in developing an effective HIV vaccine. The studies demonstrated techniques for stimulating immune cells to produce antibodies that either could stop HIV from infecting human cells in the laboratory, or had the potential to evolve into such antibodies, according to a National Institute of Allergy and Infectious Diseases press release.
HIV-specific Immune Responses Linked to Reduced Infection Risk in PrEP Study
- Details
- Category: Pre-exposure Prophylaxis (PrEP)
- Published on Friday, 03 July 2015 00:00
- Written by George Washington University
People who remained HIV-negative in the iPrEx pre-exposure prophylaxis (PrEP) trial were more likely to show evidence of HIV-specific T-cell responses, and certain responses were significantly associated with reduced risk of infection, according to research published in the June 22 advance edition of Proceedings of the National Academy of Sciences. These findings suggest that natural immunity may be giving Truvada PrEP a boost in preventing HIV infection.
Broad-Spectrum Killer T-Cells May Be Needed to Fight Latent HIV
- Details
- Category: Search for a Cure
- Published on Wednesday, 21 January 2015 00:00
- Written by HIVandHepatitis.com
Cytotoxic T-cells with a wide spectrum of activity may be necessary to detect and destroy memory CD4 T-cells containing inactive reservoir HIV from people who start antiretroviral therapy (ART) during chronic infection, according to research reported in the January 7 edition of Nature. People who start treatment very early, however, may still have non-mutated virus that is susceptible to detection by normal killer T-cells -- and a therapeutic vaccine may help boost immune responses in those treated later.
Better Dendritic Cell Recognition May Explain Stronger Response to HIV in Elite Controllers
- Details
- Category: Immune Response to HIV
- Published on Wednesday, 17 June 2015 00:00
- Written by MGH
Dendritic cells -- the first line of immune defense-- may be better able to recognize HIV in elite controllers, triggering greater cytokine production and interferon-stimulated gene expression, which ultimately results in more effective HIV-specific T-cell responses, according to research reported in the June 11 edition of PLoS Pathogens. Better understanding of this process may be helpful in the search for a functional cure, by improving T-cell immunity against HIV in people who are not natural controllers.
Broadly Neutralizing Antibodies May Prevent Reservoir HIV from Entering T-Cells
- Details
- Category: Immune Response to HIV
- Published on Thursday, 28 August 2014 00:00
- Written by Liz Highleyman
HIV-specific broadly neutralizing antibodies may be able to prevent virus emerging from latent reservoir sites from entering CD4 T-cells, as well as suppressing viral replication if HIV does manage to get in, according to NIAID research published in the August 25 advance edition of Proceedings of the National Academy of Sciences.
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